MBCP® Syringe

MBCP® Syringe is a synthetic bone graft substitute: MBCP® Technology granules in mixing delivery system, ideal for bone reconstruction.1,6,11,12
This synthetic bone graft substitute in its syringe can be combined with your osteoinductive factor like bone marrow material for bone tissue engineering 5.
It is the adapted synthetic bone graft matrix for tissue engineering5.

Orthopaedics and Maxillofacial:
It is intended for use as a bone graft to fill or reconstruct osseous bone defects or gaps of the skeletal system (e.g. extremities, spine and pelvis, dental) that are not intrinsic to the stability of the bone structure. Osseous defects can occur as a result of a trauma or in surgically created defects.
It can be used with autograft as a bone graft extender.

MBCP® Technology’s Key Features

  • Osteoconductive – Provides a matrix for new bone growth 1,2,3,16.
  • Molecular mixture of HA and TCP (60% HA – 40% TCP) 4,17,18 – HA alone resorbs too slowly while TCP resorbs too fast 4,17,18. Bi-phasic HA and TCP allow for a resorption rate similar to that of human bone 7,19,21.
  • 70% porosity, similar to cancellous bone4 – Interconnected network of macropores and micropores that enables the colonization of bone cells and biological fluid uniformly within the matrix 4,8,15,20.
  • Bioactive 1,4,16 – For ionic exchange: TCP dissolution and bone crystal precipitation create newly bioactive interface with bone cells.
  • Macroporosity 8,9,10,15,20 – Macropores are a network of interconnected spaces that promote the biological infiltration and cellular colonization by osteoblasts and osteoclasts.
  • Microporosity 8,9,10,20 – Micropores are the intercrystalline spaces where dissolution and recrystallisation occurs.
  • Granules size 500 – 1000 μm
  • > 30 years of clinical experience 1,6,11,12 – Host bone formation is demonstrated.
  • Safe 7,12,13,22 – 100% synthetic 4,17.
  • Available in: 0.5cc, 1.0cc


1. Passuti – 1989 – “Macroporous Calcium Phosphate Ceramic Performance in Human Spine Fusion” Clinical Orthopaedics
2. Rodriguez – 2008 – “Five Years Clinical follow-up Bone Regeneration with CaP bone ceramics” Key Engineering Materials
3. Kolerman – 2012 – “Clinical Radiographic and Histomorphometrical Analysis of Maxillary Sinus Augmentation using Synthetic Bone Substitute” Journal of Oral and Maxillofacial Surgery
4. Legeros – 2002 – “Properties of Osteoconductive Biomaterials: Calcium Phosphates” – Clinical Orthopedics
5. Cavagna – 1999 – “Macroporous Calcium Phosphate Ceramic : a prospective study of 106 cases in Lumbar Spinal Fusion” Journal of Long-Rerm Effects of Medical Implants
6. Rouvillain – 2009 – “Clinical, radiological and histological evaluation of biphasic calcium phosphate bioceramic wedges filling medial high tibial valgisation osteotomies” The Knee
7. Ransford – 1998 – “Synthetic porous ceramic compared with autograft in scoliosis surgery 341 patient randomised study” The Journal of Bone and Joint Surgery
8. Daculsi – 2008 – “Effect of sintering process of HA/TCP bioceramics on microstructure, dissolution, cell proliferation and Bone ingrowth” Key Engineering Materials
9. Miramond – 2014 – “Comparative critical study of commercial calcium phosphate bone substitutes in terms of physico-chemical properties” – Key Engineering Materials
10. Duan – 2017 – “Variation of bone forming ability with the physicochemical properties of calcium phosphate bone substitutes” – Article on line
11. Xie – 2006 – “Evaluation of the osteogenesis and biodegradation of porous biphasic ceramic in the human spine, 20 patients” Biomaterials
12. Pascal–Mousselard – 2006 – “Anterior Cervical Fusion With PEEK Cages: Clinical Results of a Prospective, Comparative, Multicenter and Randomized Study Comparing Iliac Graft and a Macroporous Biphasic Calcium Phosphate” North American Spine Society
13. Lavallé – 2004 – “Biphasic Ceramic wedge and plate fixation with locked adjustable screws for open wedge tibial osteotomy” Revue de chirurgie orthopédique
14. Gouin – 1996 – “Clinical applications of calcium phosphate ceramics” SOFCOT teaching supplement
15. Gauthier – 1998 – “Macroporous biphasic calcium phosphate ceramics: influence of macropore diameter and macroporosity percentage on bone ingrowth” Biomaterials
16. Cho – 2011 – “Bioactivity and osteoconductivity of biphasic calcium phosphates” Bioceramics Development and Applications
17. Nery – 1992 – “Tissue response to biphasic calcium phosphate ceramic with different ratios of HA/TCP in periodontal osseous defects” – Journal of Periodontology
18. Schaefer – 2011 – “How degradation of calcium phosphate bone substitute materials is influenced by phase composition and porosity” – Advanced Engineering Materials
19. Daculsi – 2013 – “Clinical studies of anterior cervical fusion with PEEK cages: comparing illiac graft and a Macroporous Biphasic Calcium Phosphate
20. Legeros – 1988 – “Significance of the porosity and physical chemistry of Calcium Phosphate Ceramics Biodegradation-Bioresorption
21. Daculsi – 1999 – “Spongious and cortical bone substitution kinetics at the expense of macroporous biphasic calcium phosphate: animal and human evidence” Bioceramics
22. Changseong – 2014 – “Eight-Year clinical follow-up of sinus grafts with Micro-Macroporous biphasic calcium phosphate granules” Key Engineering Materials
23. Gouin – 1995 – “Biphasic macroporous calcium phosphate ceramine bone substitute for filling bone defects: a report of 23 cases” Revue de Chirurgie Orthopédique

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